Rejuran salmon DNA injections
Rejuran is an injectable skin rejuvenation treatment that has been widely used in Asia, particularly South Korea, and is now available in Australia. It is commonly referred to as “salmon DNA injections” due to the way its key ingredients are sourced.
Rejuran is classified as a biostimulator, meaning it works by supporting the skin’s own natural regenerative processes rather than adding volume. It helps stimulate fibroblasts, the cells responsible for producing collagen and elastin, which play an important role in maintaining skin structure, elasticity, and hydration.
This process may help improve overall skin quality, including hydration, texture, and firmness. Rejuran is often discussed for concerns such as fine lines, uneven texture, enlarged pores, and scarring, including acne scarring. Individual results vary and depend on skin condition and personal factors.


What Is Rejuran?
Rejuran is formulated using polynucleotides, specifically a complex known as PDRN, which is derived from purified salmon DNA. Polynucleotides are naturally occurring molecules found in the skin and are involved in cellular repair and skin remodelling.
Salmon is used as the source because it contains a high concentration of nucleic acids. Through a specialised purification and processing method, long DNA strands are extracted and broken down into shorter, highly refined polynucleotide complexes. The final product does not contain sperm cells or intact DNA, only processed polynucleotides.
When used in injectable form, these polynucleotides are intended to support skin cell renewal and collagen production. Because of its focus on skin regeneration and quality, Rejuran is sometimes referred to as a “skin rejuvenation” or “skin repair” treatment.
Suitability for Rejuran and expected outcomes are discussed during a consultation with a qualified medical practitioner.
​​​
Frequently Asked Questions
​
1. What is Rejuran and how does it function?
Rejuran is a bio-regenerative skin treatment made of polynucleotides (PN), which are purified DNA fragments derived from wild salmon. When clinically administered into the skin, these PN molecules act as a scaffold to support the skin's natural repair mechanisms. The goal is to stimulate the production of collagen and elastin from within, intended to improve skin thickness, elasticity, and overall physiological health.
2. What should I expect during a Rejuran clinical session?
The procedure involves a series of micro-injections into the superficial layers of the skin. To prioritise patient comfort, a topical anaesthetic is typically applied prior to the session. You may notice small, visible "papules" (raised bumps) at the application sites immediately following the treatment. This is a normal part of the process and generally resolves within 24 to 72 hours as the product is absorbed by the tissue.
3. What clinical concerns can Rejuran address?
Rejuran is utilised to address a variety of skin quality concerns. It is commonly sought for improving the appearance of fine lines, refining enlarged pores, and supporting the skin's barrier function. Specialized versions of the product, such as Rejuran I (for the delicate eye area) or Rejuran S (for targeted scarring), are available to suit specific clinical needs.
4. How many sessions are recommended for the intended results?
While individual skin responses vary, a standard clinical protocol usually involves three initial sessions spaced approximately three to four weeks apart. Because the treatment relies on biological regeneration, the effects develop gradually over several weeks. To sustain the intended improvements in skin quality, maintenance sessions are typically recommended every six to twelve months.

